Peer support to improve TB and HIV treatment completion in Uganda
Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11379641
This program uses trained peer supporters to help adults with TB, including people living with HIV, stay on their TB and HIV medicines and finish treatment in Uganda.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11379641 on ClinicalTrials.gov |
What this research studies
At 16 clinics in Uganda, people newly diagnosed with TB (with or without HIV) will be offered a peer-navigation program led by trained peers who have lived experience with TB. Peers will provide TB education and adherence counseling using a checklist, help create individualized adherence plans, and deliver behavior-change messages while clinic workflows are adjusted to support these services. Clinics are randomized to offer the peer-led package or continue usual care, and researchers will follow patients' treatment adherence, completion, and clinical outcomes. Data will come from clinic records and follow-up visits to compare how well the peer approach works across sites.
Who could benefit from this research
Good fit: Adults newly diagnosed with active tuberculosis in Uganda, including people living with HIV who receive care at participating clinics, are the intended participants.
Not a fit: Children, people who are not treated at the participating Ugandan clinics, those who have already finished TB treatment, or those who decline peer support are unlikely to benefit from joining this program.
Why it matters
Potential benefit: If successful, this approach could help more people with TB—especially those living with HIV—complete treatment, lower deaths, and improve recovery.
How similar studies have performed: Earlier pilot work and peer-led programs in HIV care have shown feasibility and improved adherence, but this larger randomized trial will test those findings across many sites.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVIS, JOHN LUCIAN — YALE UNIVERSITY
- Study coordinator: DAVIS, JOHN LUCIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus