Peer support to help adolescents and young adults with sickle cell pain use cognitive behavioral therapy

Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy

NIH-funded research University of Pittsburgh at Pittsburgh · NIH-11393959

This project offers a personalized digital cognitive behavioral therapy program with peer support for adolescents and young adults with sickle cell disease, compared with self-guided CBT and usual care.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Pittsburgh at Pittsburgh NIH-funded
Lab location1 site (Pittsburgh, United States)
Project IDNIH-11393959 on NIH RePORTER

What this research studies

If you join, you'll be randomly assigned to a personalized digital CBT program plus trained peer support, a self-guided CBT program, or to continue usual care. You'll use a tailored app to learn pain-coping skills, connect with peer supporters, and regularly report pain levels, opioid use, and healthcare visits. The team partnered with community groups and the NIH HEAL network during an initial phase to adapt the program and prepare sites. They requested extra HEAL funds to address unanticipated costs and strengthen the peer support and trial rollout for the larger UH3 phase.

Who could benefit from this research

Good fit: Teenagers and young adults with sickle cell disease who experience recurrent pain and are willing to use a digital program and peer support (roughly ages 13–30).

Not a fit: People without sickle cell disease, older adults outside the target age range, or those unable or unwilling to use digital tools or engage with peer support may not benefit from this trial.

Why it matters

Potential benefit: If successful, the approach could reduce pain, lower opioid use, and decrease emergency visits and hospitalizations for adolescents and young adults with sickle cell disease.

How similar studies have performed: Cognitive behavioral therapy and digital CBT have shown benefits for pain and stress in prior studies, but combining personalized digital CBT with structured peer support is relatively new for this group.

Where this research is happening

Pittsburgh, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.