Peer-led support for people who use drugs after hospital discharge

THRIVE: Teaching Health promotion and Resilience in Varied Environments: a peer-led intervention following hospital discharge

NIH-funded research University of Pennsylvania · NIH-11364494

A 12-week peer-led program to help people who use drugs stay safer and healthier after leaving the hospital.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-11364494 on NIH RePORTER

What this research studies

You would meet a peer with lived experience around the time you leave the hospital or emergency department, then get weekly text messages and electronic materials for 12 weeks to reinforce what you talked about. The program content was co-created with people who use drugs and is based on behavior-change models, then tailored to patients using a human-centered design process. The team will work with hospital and ED staff to make the program practical and acceptable in those clinical settings. The goal is to change behaviors that lead to overdose and injection-related harms.

Who could benefit from this research

Good fit: Ideal candidates are adults who use drugs who are being discharged from a hospital or emergency department and can receive texts or access electronic content.

Not a fit: People who do not use drugs, cannot be contacted after discharge, or have conditions that prevent participation (for example severe cognitive impairment) are unlikely to benefit.

Why it matters

Potential benefit: If successful, this program could lower overdose and infection risks and help people who use drugs stay healthier after a hospital visit.

How similar studies have performed: Previous peer-support and text-message interventions have shown promise in reducing risky behaviors, but a tailored, hospital-delivered bundle like this is relatively novel.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.