PEDF protein to protect the brain after aneurysmal subarachnoid hemorrhage
Official title: Novel neurovascular protective mechanisms of PEDF after subarachnoid hemorrhage
Funded at Loma Linda University · NIH-11232362 · Data updated 2026-11-12
This work looks at whether a natural protein called PEDF can protect the brain and its blood vessels after bleeding from a brain aneurysm.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project start | December 1, 2021 |
| Project end | November 30, 2026 |
| Funding year | 2026 |
| Award (this year) | $405,000 |
| NIH project number | 5R01NS117179-05 |
| Project ID | NIH-11232362 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who have experienced an aneurysmal subarachnoid hemorrhage (bleeding around the brain), especially early after the bleed, are the population most relevant to this work.
✕Less likely to help
Patients without aneurysmal SAH or with unrelated neurological conditions are unlikely to receive direct benefit from this specific research.
What this research studies
Researchers will use laboratory models of aneurysmal subarachnoid hemorrhage (SAH), including rodent models and cultured brain cells, to study how PEDF affects neurons and blood vessels. They will increase or deliver PEDF and measure outcomes such as blood-brain barrier leakage, brain swelling (edema), neuronal death, and inflammatory signals. The team will use imaging, molecular assays, and tissue analyses to map the signaling pathways by which PEDF may provide protection. The overall aim is to identify mechanisms that could guide development of therapies to reduce early brain injury after SAH.
Why it matters
Potential benefit: If successful, this work could point to new treatments that limit brain swelling and blood-vessel injury after aneurysmal SAH, potentially reducing death and long-term disability.
How similar studies have gone: Prior laboratory studies show PEDF can reduce neuronal death and brain edema in some ischemic stroke and injury models, but applying PEDF to subarachnoid hemorrhage is new.
Where this research is happening
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Loma Linda University
Loma Linda, United States Active
Researchers
- Principal investigator: Zhang, John H — Loma Linda University
- Study coordinator: Zhang, John H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.