Patient-specific 4D maps of brain blood vessels
Generating High Quality, High Resolution, Patient-Specific 4D Models of Cerebral Vasculature
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11307005
Using routine angiogram videos to build moving 3D maps of your brain's blood vessels to help people with stroke, aneurysms, or other blood-vessel problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11307005 on ClinicalTrials.gov |
What this research studies
If I take part, the team will use the angiogram videos collected during my care to create a high-resolution, moving 3D model of my brain's blood vessels. They will develop new software to trace vessel edges in the images, capture how blood flows over time, and combine that information to produce a '4D' reconstruction (3D plus time). The approach aims to get finer spatial and temporal detail than current clinical scans without needing extra radiation or contrast. These models could be used before or during procedures to help plan and monitor treatment.
Who could benefit from this research
Good fit: Ideal candidates are people with stroke, aneurysm, arteriovenous malformation, or other cerebrovascular conditions who undergo cerebral angiography (DSA) as part of their care.
Not a fit: People without cerebrovascular disease or those not undergoing DSA angiography (or who cannot safely have angiography) are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this could help doctors plan and monitor treatments more precisely, potentially reducing risks and improving outcomes for people with neurovascular conditions.
How similar studies have performed: Previous work has shown 2D-to-3D reconstruction is feasible, but producing high-resolution, time-resolved (4D) patient-specific models from routine DSA is a novel approach still under development.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRISKEN, SARAH — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: FRISKEN, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury