Patient-focused program to reduce unnecessary antibiotics in outpatient care

Patient-Centered Stewardship to Improve Antibiotic Use in Ambulatory Care

NIH-funded research Northwestern University · NIH-11115655

This project will use patient-directed messages and support to help people who frequently get antibiotics avoid unnecessary antibiotic use.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNorthwestern University NIH-funded
Lab location1 site (Chicago, United States)
Project IDNIH-11115655 on NIH RePORTER

What this research studies

The team will review medical records from two large health systems to find patients who receive antibiotics often and classify whether those prescriptions were appropriate. They will conduct interviews with people identified as high antibiotic users to understand the reasons and concerns behind their care-seeking and antibiotic use. Using what patients say, researchers will design a brief, patient-centered behavioral nudge (like tailored messages or reminders) and test it in a small randomized pilot. If you get care in the participating clinics, you might be invited to share your experiences or receive the nudge to see whether it changes antibiotic use.

Who could benefit from this research

Good fit: Ideal candidates are adults or children in the participating outpatient clinics who have had multiple recent antibiotic prescriptions or are identified as high antibiotic users.

Not a fit: Patients whose antibiotic use is already appropriate, who receive care outside the participating health systems, or who are hospitalized are unlikely to benefit directly from this project.

Why it matters

Potential benefit: If successful, this approach could reduce unnecessary antibiotic prescriptions, lower side effects, and help slow the spread of antibiotic resistance.

How similar studies have performed: Prior efforts focused on clinician-targeted strategies produced modest improvements in prescribing, while patient-centered behavioral nudges are less tested but show promise.

Where this research is happening

Chicago, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.