Patient-derived ovarian cancer models for testing new treatments
Core D: Animal Models
['FUNDING_OTHER'] · MAYO CLINIC ROCHESTER · NIH-11178537
Using tumors taken from people with ovarian cancer to grow models in mice and 3D lab cultures so researchers can test new therapies that better match patient tumors.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11178537 on ClinicalTrials.gov |
What this research studies
This core grows tumors taken from people with ovarian cancer into mice and into 3D lab cultures so treatments can be tried on models that behave like real tumors. The models reproduce key patient features such as spread in the abdomen and buildup of ascites and often mirror how patients respond to platinum/taxane chemotherapy. The core shares models and data with biostatistics, bioinformatics, and biospecimen teams to support multiple treatment-development projects. If I donate tumor tissue or ascites during my care at Mayo Clinic, my sample could become part of this model collection used to develop new therapies.
Who could benefit from this research
Good fit: People with ovarian cancer who are willing to donate tumor tissue or ascites during surgery or clinical care for research use would be ideal candidates for contributing to this core.
Not a fit: Patients who cannot or prefer not to donate tissue, or those without ovarian cancer, would not directly participate or benefit from this core's activities.
Why it matters
Potential benefit: Could speed development of treatments that more closely reflect how ovarian tumors behave in patients.
How similar studies have performed: Patient-derived xenografts and 3D culture methods are well-established and often mirror patient chemotherapy responses, though turning those findings into new approved treatments remains challenging.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEROHA, SARAVUT — MAYO CLINIC ROCHESTER
- Study coordinator: WEROHA, SARAVUT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.