Pathways of fatty acid oxidation and how it harms cells
Official title: Pathways of peroxidation: defining the autoxidation of polyunsaturated fatty acids and the cellular consequences
Funded at Louisiana State Univ A&m Col Baton Rouge · NIH-11381800 · Data updated 2026-11-12
This grant explores how fats in our cells naturally change in ways that can hurt us, and what that means for diseases like cancer, heart disease, diabetes, and dementia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $369,174 |
| NIH project number | 5R35GM154857-03 |
| Project ID | NIH-11381800 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory or chronic diseases linked to oxidative stress may benefit from insights gained, especially if future therapies target these pathways.
✕Less likely to help
Direct benefits are not guaranteed for healthy individuals or those without inflammatory or oxidative stress-related conditions.
What this research studies
Researchers will study how essential fats called polyunsaturated fatty acids are oxidized inside cells and how the byproducts damage mitochondrial proteins. They will map where these lipid-derived toxins come from and how they are formed, with a focus on mitochondria. The work aims to connect these chemical changes to broader inflammation and disease processes in humans. The study uses cellular and biochemical models to understand a problem that may affect many chronic conditions.
Why it matters
Potential benefit: Understanding these pathways could lead to new strategies to prevent or reduce damage from inflammatory diseases.
How similar studies have gone: Previous work has shown that lipid oxidation products can modify proteins and contribute to disease, but detailed pathway mapping in human cells remains an active field.
Where this research is happening
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Louisiana State Univ A&m Col Baton Rouge
Baton Rouge, United States Active
Researchers
- Principal investigator: Beavers, William Norris — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Beavers, William Norris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.