Pathology and tumor tissue resource supporting glioma therapies
Core 1: Pathology Core
This program provides tumor samples, lab-grown tumor models, and pathology support to help create targeted treatments for people with glioma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11178599 on NIH RePORTER |
What this research studies
If my tumor is included, the team will collect and store my tumor tissue along with clinical and pathology information. They will create and share patient-derived models such as organoids, neurospheres, cell lines, and animal grafts for lab testing. The core also helps run clinical trials by processing and characterizing tumor samples and coordinating sample distribution. Work focuses on tumors with changes like BRAF, IDH, and H3F3A to speed development of targeted therapies.
Who could benefit from this research
Good fit: People with gliomas, especially those whose tumors have mutations such as BRAF, IDH, or H3F3A, including both children and adults, are ideal candidates to contribute samples or enroll in related trials.
Not a fit: People without glioma or whose tumors lack the specific molecular targets studied are unlikely to directly benefit from this core resource.
Why it matters
Potential benefit: This resource could speed development of better targeted treatments and matching of patients to therapies for glioma.
How similar studies have performed: Previous tumor-biorepository and pathology cores have helped enable biomarker-driven trials and model development, though some approaches here (like strategies against IDH-inhibitor resistance) are novel.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ligon, Keith Lloyd — Brigham and Women's Hospital
- Study coordinator: Ligon, Keith Lloyd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.