Pain-relieving targets from patient antibodies: CRMP5/GluN2B signaling in neuropathic pain
Official title: Anti-CV2 autoantibodies unmask a CRMP5/GluN2B pain signaling hub
Funded at Saint Louis University · NIH-11321650 · Data updated 2026-11-12
This grant explores how autoantibodies in patients with neuropathic pain may uncover new targets to relieve persistent pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 14, 2022 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $351,855 |
| NIH project number | 5R01NS119263-06 |
| Project ID | NIH-11321650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with neuropathic pain or related conditions who may contribute patient-derived samples for research.
✕Less likely to help
Individuals without neuropathic pain or with conditions not connected to the CRMP5 pathway may not benefit.
What this research studies
Neuropathic pain affects millions and current drugs often fail or cause bad side effects. This project uses human samples to study how autoantibodies against CRMP5 influence pain signaling in nerve cells, aiming to connect basic science findings with what patients experience. By focusing on the CRMP5/GluN2B hub in sensory neurons, the work seeks to translate lab discoveries into more targeted therapies for people with neuropathic pain. The study combines laboratory experiments with patient-derived materials to improve relevance to real-world pain management.
Why it matters
Potential benefit: If successful, the research could lead to new, more effective treatments for neuropathic pain with fewer side effects.
How similar studies have gone: Previous work suggests autoantibodies can influence pain signaling, supporting the potential for meaningful advances in this area.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Moutal, Aubin — Saint Louis University
- Study coordinator: Moutal, Aubin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.