p300's role in airway smooth muscle and asthma remodeling
Official title: p300 in Airway Smooth Muscle
Funded at Albany Medical College · NIH-11366264 · Data updated 2026-11-12
Researchers are studying how a protein called p300 affects airway smooth muscle growth and remodeling in asthma to identify new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | September 18, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $589,372 |
| NIH project number | 1R01HL180713-01A1 |
| Project ID | NIH-11366264 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with asthma or healthy volunteers providing airway tissue samples may participate depending on the specific study component.
✕Less likely to help
Some participants may not directly benefit if they are not experiencing airway remodeling or do not contribute to specific molecular analyses.
What this research studies
This project looks at how p300, a molecule that helps control gene activity, influences the growth of airway smooth muscle cells and airway remodeling seen in asthma. The work includes laboratory studies on human airway smooth muscle cells and animal models to understand how p300 affects growth signals and chromatin structure. By outlining the role of p300 in allergen-driven changes in the airways, the study aims to uncover potential targets for new therapies. If successful, the findings could pave the way for treatments that reduce airway thickening and improve breathing for people with asthma.
Why it matters
Potential benefit: If successful, the research could lead to new therapies that lessen airway remodeling and improve symptoms for people with asthma.
How similar studies have gone: Previous research has linked p300 to transcription and cellular growth, but its exact role in airway smooth muscle remodeling in asthma is still being explored.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Tang, Dale D. — Albany Medical College
- Study coordinator: Tang, Dale D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.