Oral microbiome and inflammation in treated oral cancer patients
Official title: Oral microbiome and inflammatory status in antimicrobially-treated oral cancer patients
Funded at University of California Los Angeles · NIH-11374782 · Data updated 2026-11-12
This grant supports research on how the mouth's microbiome and inflammation affect people who have been treated for oral cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 13, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $626,403 |
| NIH project number | 5R01CA269950-06 |
| Project ID | NIH-11374782 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have been treated for oral squamous cell carcinoma and are within follow-up care.
✕Less likely to help
Patients without oral cancer or those not receiving antimicrobial treatment may not benefit from this research.
What this research studies
Researchers will study whether oral bacteria and inflammatory markers change after antimicrobial treatment in patients with oral cancer, and how these changes relate to health outcomes. The study uses patient samples and clinical data to understand links between the mouth’s ecosystem, treatment effects, and cancer control. Findings could point to new ways to support recovery and prevent recurrence through microbiome- and inflammation-focused strategies.
Why it matters
Potential benefit: If successful, the work could lead to interventions that improve recovery and reduce recurrence for oral cancer patients by targeting the oral microbiome and inflammation.
How similar studies have gone: Previous work suggests the oral microbiome and inflammation are linked to cancer outcomes, but targeted human studies in treated OSCC patients are still evolving.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Kapila, Yvonne L — University of California Los Angeles
- Study coordinator: Kapila, Yvonne L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.