Oral Bicarbonate and Heart Health in Kidney Disease
Cardiovascular effects of oral bicarbonate in CKD
['FUNDING_R01'] · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · NIH-11159504
This project looks at how taking sodium bicarbonate for kidney disease might affect your heart and blood vessels.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11159504 on ClinicalTrials.gov |
What this research studies
Many people with chronic kidney disease (CKD) develop a condition called metabolic acidosis, which is often treated with sodium bicarbonate. While this treatment helps with bone and muscle health, there are concerns it might also affect heart health. This research aims to understand if sodium bicarbonate causes the body to hold onto too much salt and fluid, which could raise blood pressure. It also explores if this treatment might contribute to the hardening of blood vessels, known as vascular calcification. By studying these effects, we hope to learn how to better protect the hearts of individuals with CKD.
Who could benefit from this research
Good fit: This research focuses on individuals living with chronic kidney disease who may be receiving or considering treatment with sodium bicarbonate for metabolic acidosis.
Not a fit: Patients without chronic kidney disease or metabolic acidosis would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help doctors understand the best ways to treat acidosis in kidney disease patients while protecting their heart health.
How similar studies have performed: While individual trials have not shown substantial increases in body weight or blood pressure, a meta-analysis suggested a higher risk of needing more blood pressure medication or diuretics, indicating some prior findings support the concerns this project addresses.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAPHAEL, KALANI LUKELA — UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- Study coordinator: RAPHAEL, KALANI LUKELA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.