Optimizing semi-open catheters to improve CSF flow
Official title: Optimizing Semi-Open Catheter Design for Cerebrospinal Fluid Flow Using Computational and Rapid In Vitro Screening
Funded at Mississippi State University · NIH-11440476 · Data updated 2026-11-12
A small research grant tests a new semi-open catheter design to help CSF flow in people with hydrocephalus.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mississippi State University NIH-funded |
| Lab location | 1 site (Mississippi State, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $146,500 |
| NIH project number | 1R03NS151556-01 |
| Project ID | NIH-11440476 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with hydrocephalus who rely on ventricular shunts; future applicability to those considering shunt optimization.
✕Less likely to help
Early-stage, non-shunt hydrocephalus patients or those not requiring shunts may not benefit.
What this research studies
Hydrocephalus can require ventricular shunts to divert CSF, but many shunts fail within a couple of years due to blockage. This project uses computer models and quick lab screening to compare semi-open catheter tips with traditional designs under realistic brain fluid conditions. The goal is to find a low-cost, reproducible way to predict and improve catheter performance so fewer patients need repeat surgeries. If successful, the approach could guide future device improvements and testing before human use.
Why it matters
Potential benefit: If the design proves better, patients may experience fewer shunt obstructions and related surgeries.
How similar studies have gone: Previous designs showed mixed results; this study emphasizes physiologic realism and rapid screening to improve predictability.
Where this research is happening
-
Mississippi State University
Mississippi State, United States Active
Researchers
- Principal investigator: Miralami, Raheleh — Mississippi State University
- Study coordinator: Miralami, Raheleh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.