Optimizing medication management for delirium in Alzheimer's patients after hospitalization
A targeted analytical framework to optimize posthospitalization delirium pharmacotherapy in patients with Alzheimers disease and related dementias
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11077290
This study is looking at how to better manage delirium in people with Alzheimer's and similar conditions while they're in the hospital, focusing on safely using and stopping antipsychotic medications to help them recover without extra side effects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11077290 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the management of delirium, a common and serious condition affecting individuals with Alzheimer's disease and related dementias during hospital stays. The study aims to develop a targeted framework to optimize the use of antipsychotic medications, which are often prescribed off-label to manage delirium symptoms. By addressing the challenges of safely discontinuing these medications after hospitalization, the research seeks to enhance patient recovery and minimize adverse effects. The approach involves analyzing existing clinical data to inform best practices for medication management in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Alzheimer's disease or related dementias who experience delirium during hospitalization.
Not a fit: Patients who do not have Alzheimer's disease or related dementias, or who do not experience delirium during hospitalization, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment protocols for managing delirium in patients with Alzheimer's disease and related dementias.
How similar studies have performed: While there is limited direct evidence from randomized control trials on this specific approach, similar research has highlighted the importance of careful medication management in frail elderly populations.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIN, JOSHUA K — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: LIN, JOSHUA K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease and related dementia