Optimizing infliximab treatment for children with Crohn's disease
Precise Infliximab Exposure and Pharmacodynamic Control to Achieve Deep Remission in Pediatric Crohn's Disease
This study is looking to help kids with Crohn's disease by figuring out the best dose of a medicine called infliximab just for them, so they can feel better and heal their intestines more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11083748 on NIH RePORTER |
What this research studies
This research focuses on improving treatment for pediatric patients with Crohn's disease by using a personalized approach to infliximab dosing. It aims to develop a decision support system that tailors medication doses based on individual patient responses and pharmacokinetic data. By monitoring drug levels and adjusting doses accordingly, the study seeks to enhance the chances of achieving deep remission and intestinal healing in children suffering from this chronic condition. The approach is designed to be scalable and applicable throughout the duration of treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 18 years old who are diagnosed with moderate to severe Crohn's disease and are starting treatment with infliximab.
Not a fit: Patients who are not diagnosed with Crohn's disease or those who are older than 18 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly increase the rates of remission and healing in children with Crohn's disease, leading to improved quality of life.
How similar studies have performed: Previous studies have shown success with similar pharmacodynamic monitoring approaches in improving treatment outcomes for patients with Crohn's disease.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Minar, Phillip P — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Minar, Phillip P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.