Optimizing excess glucose handling in the proximal small intestine for diabetes care
Official title: Numerical Experimentation of the Therapeutic Effect of Excess Glucose Transglycosylation and Optimization in the Proximal Small Intestine.
Funded at Prairie View Agri & Mech University · NIH-11355641 · Data updated 2026-11-12
Aimed at improving how the gut manages too much glucose to help adults with type 2 diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Prairie View Agri & Mech University NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $175,935 |
| NIH project number | 5R16GM154691-03 |
| Project ID | NIH-11355641 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Type 2 diabetes or related metabolic conditions who have or are at risk for NAFLD.
✕Less likely to help
Patients without metabolic disease or liver involvement may not directly benefit from this specific study.
What this research studies
This project looks at how the upper small intestine processes and trims excess glucose and fructose from the diet, with a focus on improving liver health and reducing fat buildup. Researchers will model and test how changes in the proximal SI affect nutrient handling and bioavailability. The work is designed to translate into methods that could lessen NAFLD risk and improve overall glucose control for patients, potentially guiding future treatments or dietary strategies.
Why it matters
Potential benefit: If successful, the work could lead to better management of blood sugar and liver fat in adults with diabetes.
How similar studies have gone: Previous research suggests gut-based nutrient handling can influence metabolic outcomes, but this approach is exploratory and novel in its specific proximal SI optimization.
Where this research is happening
-
Prairie View Agri & Mech University
College Station, United States Active
Researchers
- Principal investigator: Olanrewaju, Kazeem — Prairie View Agri & Mech University
- Study coordinator: Olanrewaju, Kazeem
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.