Optimizing donor immune cells to improve outcomes in stem cell transplants
Using donor dendritic cells to optimize GvHD and GvL in allogeneic stem cell transplantation
This study is looking at how to make stem cell transplants safer and more successful by focusing on special immune cells from donors that can help reduce complications and improve survival for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10896196 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of allogeneic stem cell transplants by identifying and enriching specific populations of donor dendritic cells. These immune cells play a crucial role in reducing graft-versus-host disease (GvHD) and improving patient survival rates. The study will investigate how these dendritic cells function and how they can be effectively collected and utilized in clinical settings. By understanding the mechanisms behind these cells, the research aims to develop better transplant protocols that minimize complications and improve outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing allogeneic stem cell transplantation who are at risk for graft-versus-host disease.
Not a fit: Patients who are not undergoing stem cell transplantation or those with conditions unrelated to GvHD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and reduced complications for patients undergoing stem cell transplants.
How similar studies have performed: Previous research has shown promising results in using dendritic cells to improve transplant outcomes, indicating that this approach has potential for success.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Waller, Edmund K — Emory University
- Study coordinator: Waller, Edmund K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.