Optimizing dolutegravir treatment for children and teens with HIV
Addressing Research Gaps to Optimize Dolutegravir-based ART in Children and Adolescents
Looks at ways to make dolutegravir-based HIV treatment work better and safer for children and adolescents.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11393207 on NIH RePORTER |
What this research studies
This project focuses on children and adolescents living with HIV to fill gaps in how the drug dolutegravir (DTG) is given and used. Researchers will study weight-band dosing for the 10 mg dispersible tablet, check for important drug-drug interactions, and monitor viral suppression and side effects. The work will combine clinical data, pharmacology measurements, and patient samples from participating clinics to refine dosing and safety guidance. Findings aim to support safer, simpler DTG use for young people, especially in resource-limited settings.
Who could benefit from this research
Good fit: Children and adolescents living with HIV who are starting or switching to dolutegravir-based ART and who receive care at participating clinics are the ideal candidates.
Not a fit: Adults, people not using dolutegravir, or those without access to participating sites are unlikely to directly benefit from this project.
Why it matters
Potential benefit: Could provide clearer dosing rules and safer, more effective dolutegravir treatment for children and adolescents with HIV.
How similar studies have performed: Prior work shows dolutegravir is highly effective in adults and promising in children, but pediatric dosing and interaction data remain incomplete.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Kwara, Awewura Jacob — University of Florida
- Study coordinator: Kwara, Awewura Jacob
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.