Optimizing dolutegravir HIV treatment for children and teens
Addressing Research Gaps to Optimize Dolutegravir-based ART in Children and Adolescents
Looking at better dosing and use of the HIV drug dolutegravir to help children and adolescents living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11160800 on NIH RePORTER |
What this research studies
If your child joins, researchers will monitor how the pediatric dolutegravir tablet performs across different ages and weight bands by measuring drug levels, viral load, and side effects. The project will also check for interactions with other medicines commonly used in children, especially in low- and middle-income settings. Study staff may collect blood samples, review treatment records, and follow participants' adherence and health outcomes over time. The goal is to fill gaps in pediatric dosing and safety to guide clearer treatment recommendations.
Who could benefit from this research
Good fit: Children and adolescents living with HIV who are on or eligible to start dolutegravir-based antiretroviral therapy, across the relevant pediatric weight bands, would be ideal candidates.
Not a fit: Children who are not taking dolutegravir, adults, or those who cannot attend participating clinics are unlikely to receive direct benefit from this grant's work.
Why it matters
Potential benefit: Could make dolutegravir dosing safer and more effective for children and adolescents, improving viral suppression and reducing side effects.
How similar studies have performed: Dolutegravir has worked very well in adults and growing pediatric data are promising, but key dosing and interaction questions in children remain incompletely answered.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Kwara, Awewura Jacob — University of Florida
- Study coordinator: Kwara, Awewura Jacob
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.