Optimizing antibiotic use to prevent infections after abdominal surgery
Precision coordination of therapeutic and prophylactic antibiotics to reduce infection, toxicity, and emergence of resistance following acute abdominal surgery
This study is looking at how to best use antibiotics for people having surgery for appendicitis to help prevent infections and make recovery easier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10893957 on NIH RePORTER |
What this research studies
This research focuses on improving the use of antibiotics during and after surgery for acute appendicitis, a common emergency procedure. It aims to determine the best way to combine therapeutic antibiotics, which are given before surgery, with prophylactic antibiotics, which are intended to prevent infections during the operation. By studying the timing and types of antibiotics used, the research seeks to reduce the risk of surgical site infections and complications like pelvic abscesses. Patients undergoing appendectomy may benefit from this approach, as it aims to enhance their recovery and minimize infection rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals scheduled for appendectomy due to acute appendicitis.
Not a fit: Patients who are not undergoing surgery for appendicitis or those with complicated appendicitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of infections and complications following appendectomy, leading to better patient outcomes.
How similar studies have performed: Previous research has shown that optimizing antibiotic protocols can lead to improved outcomes in surgical patients, suggesting that this approach may be effective.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Pai, Manjunath P — University of Michigan at Ann Arbor
- Study coordinator: Pai, Manjunath P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.