One-visit low-cost HPV self-test with same-day treatment
Single Visit Clinical Validation of ScreenFire, a Low-Cost HPV Test: Efficacy and Cost Effectiveness (SCALE)
This will test a low-cost HPV self-test that lets women collect their own sample and get same-day care if needed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11308310 on NIH RePORTER |
What this research studies
You would use a simple kit to collect your own vaginal sample and get a rapid HPV result during a single clinic visit. If the test is positive, clinics would offer immediate, same-day treatment so you don't need to return later. The project compares a new low-cost test (AmpFire) to existing options to see how well it works on self-collected samples. Researchers will also look at costs and how easy the approach is to use in low- and middle-income settings so it can be scaled up.
Who could benefit from this research
Good fit: Women eligible for cervical cancer screening at participating clinics—especially in low- and middle-income settings—who can self-collect a sample would be ideal candidates.
Not a fit: People who cannot or prefer not to self-collect samples, men, or those with advanced cervical cancer needing more extensive care are unlikely to benefit directly from this trial.
Why it matters
Potential benefit: If successful, this approach could allow affordable, same-day HPV screening and treatment that reduces missed follow-up and lowers cervical cancer rates.
How similar studies have performed: Previous low-cost HPV tests have had mixed results with self-sampling, but early data for AmpFire show promising sensitivity, making this single-visit validation an important next step.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Cremer, Miriam — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Cremer, Miriam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.