One-inhaler daily-and-rescue asthma treatment for children
Single Maintenance And Reliever Therapy Strategies for Implementation and Effectiveness Trial
This project offers a single inhaler approach for children with moderate to severe asthma to simplify daily care and reduce flare-ups.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11193776 on NIH RePORTER |
What this research studies
If your child is treated at one of the participating pediatric clinics, clinicians will be supported to identify kids who could use a single maintenance-and-reliever inhaler (SMART) and given tools to teach families how to use it. Clinics are randomly assigned to receive decision support, provider training, patient education, and system-level fixes versus usual care, and researchers will follow children over time to see how well the approach works in real practice. The team will track medication use, symptoms, asthma attacks, and insurance/administration barriers to using SMART. The study focuses on pediatric patients within a large U.S. health system and aims to address common problems like poor daily adherence and inhaler confusion.
Who could benefit from this research
Good fit: Children (ages 0–11) with moderate to severe bronchial asthma who receive care at participating pediatric primary care clinics and use inhaler therapy are the best fit for this effort.
Not a fit: Children with very mild intermittent asthma, those who cannot use inhalers properly, or those with contraindications to the inhaler medications may not benefit from this approach.
Why it matters
Potential benefit: If successful, this could make inhaler routines simpler for children, improve daily medication use, and lower the number of asthma attacks.
How similar studies have performed: International real-world studies have shown SMART can improve adherence and outcomes, but it has not been widely tested in U.S. pediatric populations.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kenyon, Chen Collin — Children's Hosp of Philadelphia
- Study coordinator: Kenyon, Chen Collin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.