On-demand nonhormonal male birth control targeting the sperm enzyme sAC (ADCY10)
On-demand nonhormonal male contraception via ADCY10 inhibition
['FUNDING_OTHER'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11101382
An oral, nonhormonal pill for men to take shortly before sex that temporarily stops sperm from moving to prevent pregnancy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11101382 on ClinicalTrials.gov |
What this research studies
Sperm need an enzyme called sAC (ADCY10) to start swimming and fertilize an egg, and blocking this enzyme can make males temporarily unable to father children. Researchers are developing short-acting drug molecules that block sAC so a man could take a pill shortly before sex and have reversible contraception. The work includes improving how well the molecules bind sAC, making them absorbable by mouth, and checking safety and effectiveness in lab and animal tests as a step toward human testing. The ultimate aim is a safe, fast-acting, orally available male contraceptive that is used only when needed.
Who could benefit from this research
Good fit: Men who are biologically male, sexually active, and seeking a temporary, on-demand contraceptive option would be ideal candidates for future participation.
Not a fit: This approach would not suit people seeking permanent sterilization, women, or men who plan to conceive soon or who cannot take oral medications.
Why it matters
Potential benefit: Could give men a safe, reversible, on-demand nonhormonal contraceptive they take shortly before sex.
How similar studies have performed: Animal studies and genetic knockout experiments show blocking sAC makes male mice infertile, but an on-demand pill for people remains experimental and unproven in humans.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEVIN, LONNY R — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: LEVIN, LONNY R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.