Omics center to find why acute pain becomes chronic
Omics Data Generation Center (ODGC) for the Acute to Chronic Pain Signatures (A2CPS) Program
This project uses blood and other samples from adults who had recent surgery or injury to find biological signs that predict who will develop long-term pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11322288 on NIH RePORTER |
What this research studies
You would be part of a large effort where clinical sites enroll adults after a specific surgery or musculoskeletal injury and collect samples and symptom information over time. Blood and other biofluids are collected at the time of the acute event, then again at about 3 and 6 months, and sent to a central lab for multi-omics testing. The lab will look at many kinds of molecular data to validate 40 proposed biomarkers and to discover new markers linked to developing chronic pain. Results aim to show patterns that separate people who recover from those who go on to long-term pain, which could guide future prevention.
Who could benefit from this research
Good fit: Adults (21+) who recently experienced a qualifying surgical procedure or a specific musculoskeletal trauma and can attend baseline and follow-up visits for sample collection are ideal candidates.
Not a fit: People without a recent acute pain event, anyone under 21, or those unable or unwilling to provide samples and follow-up visits would not be eligible and would not directly benefit from participating.
Why it matters
Potential benefit: If successful, this work could produce tests that identify people at high risk for chronic pain so they can get targeted prevention earlier.
How similar studies have performed: Smaller studies have suggested molecular markers may link to chronic pain risk, but large-scale multi-omics validation like this is relatively new.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Laurent, Louise Chang — University of California, San Diego
- Study coordinator: Laurent, Louise Chang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.