Omega-3 and omega-6 fats and inflammation in pancreatic cancer
Official title: Understanding omega-3 and 6 fatty acid dependent regulation of inflammatory signals in pancreatic cancer
Funded at Salk Institute for Biological Studies · NIH-11397617 · Data updated 2026-11-12
This grant explores how fats from omega-3 and omega-6 families influence inflammatory signals that affect pancreatic cancer in humans.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $735,224 |
| NIH project number | 5U01CA293476-02 |
| Project ID | NIH-11397617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with pancreatic cancer or high risk for PDAC, especially those with obesity-related inflammatory profiles.
✕Less likely to help
Individuals without pancreatic disease or obesity-related inflammation may not directly benefit from this research.
What this research studies
Pancreatic cancer is extremely deadly and linked to chronic inflammation. The project studies how dietary fats and their inflammatory mediators shift during disease, aiming to uncover routes to restore normal tissue healing and prevent cancer progression. Researchers will examine the lipid-derived signals that switch from promoting inflammation to resolving it, focusing on omega-3 and omega-6 fatty acids. The work could point toward nutritional or therapeutic strategies to support people at risk or living with pancreatic cancer.
Why it matters
Potential benefit: If successful, the research could lead to new strategies to reduce inflammation and slow pancreatic cancer progression in patients.
How similar studies have gone: Previous work has linked fatty acid–derived signaling to inflammation and cancer, with emerging evidence for lipid mediators in tumor environments.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Kaech, Susan M — Salk Institute for Biological Studies
- Study coordinator: Kaech, Susan M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.