NRF2-FBP1 cross-regulation in liver metabolism and disease
Official title: The NRF2-FBP1 crossregulatory loop and the control of healthy and diseased liver metabolism
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-11353873 · Data updated 2026-11-12
A liver-focused study looks at how two key metabolic regulators, NRF2 and FBP1, interact to influence sugar production and liver health in disease and during fasting.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $747,010 |
| NIH project number | 5R01DK133448-06 |
| Project ID | NIH-11353873 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with liver metabolic disorders or those at risk of insulin resistance and hepatic steatosis.
✕Less likely to help
Healthy individuals without liver metabolic issues may have limited direct benefit.
What this research studies
This project explores how activating NRF2 in liver cells affects FBP1 and the body’s glucose production, fat storage, and insulin signaling. It uses mouse models with targeted NRF2 activation or FBP1 deletion in hepatocytes to uncover the crosstalk between these pathways. By mapping signaling events that link NRF2 to FBP1 degradation and how FBP1 status impacts AKT signaling, the study aims to explain metabolic changes seen in liver disease and metabolic stress. The findings could point to new approaches for managing liver metabolism and related conditions in people.
Why it matters
Potential benefit: Better understanding of liver metabolism could lead to new strategies to treat fatty liver disease and metabolic complications.
How similar studies have gone: Previous work shows NRF2 and metabolic genes influence liver metabolism; this study investigates a novel regulatory loop.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Karin, Michael — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Karin, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.