NOTCH4's role in severe asthma in urban schoolchildren
Novel NOTCH4 Pathway of Asthma Severity in Urban School Children: Clinical Research Center, Boston Children’s Hospital
Researchers are looking at how changes in the NOTCH4 pathway relate to worse asthma in urban schoolchildren to help understand why some kids have more severe symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11321081 on NIH RePORTER |
What this research studies
If your child joins, clinicians will collect clinical information, allergy and lung tests, and blood or other samples to study immune and genetic features related to asthma severity. The team will link these human samples with lab studies of the NOTCH4 pathway and with data about environmental exposures from schools and clinics. The project uses participants recruited from Boston Children's Hospital clinics and ongoing inner-city school cohorts, with careful data management and follow-up. Findings will be compared across children with different asthma severity to spot patterns that could point to future treatments.
Who could benefit from this research
Good fit: School-aged children from urban/inner-city communities who have asthma and are able to attend visits at Boston Children's Hospital or affiliated clinics would be typical candidates.
Not a fit: Adults without asthma or people whose asthma is not related to the pathways studied, as well as anyone unable to attend the study clinics, are unlikely to receive direct benefit from participation.
Why it matters
Potential benefit: This work could help identify biological markers or targets that lead to better ways to predict, prevent, or treat severe asthma in urban children.
How similar studies have performed: Prior inner-city asthma and genetics studies have identified immune and environmental contributors to severe asthma, but focusing on NOTCH4 is a newer direction with limited direct clinical precedent.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Phipatanakul, Wanda — Boston Children's Hospital
- Study coordinator: Phipatanakul, Wanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.