Nonpeptide HIV protease inhibitors
Design & Synthesis of Nonpeptide Protease Inhibitors
Developing new nonpeptide drugs that block HIV protease to help people living with HIV, including those with drug-resistant virus and brain-related complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11330250 on NIH RePORTER |
What this research studies
Researchers are designing and chemically making a new class of nonpeptide protease inhibitors aimed at treating HIV. The team will test these compounds in lab models relevant to HIV, optimize them for longer action and better penetration into the brain, and check activity against drug-resistant HIV strains. Work is highly collaborative across medicinal chemistry and biological testing groups to move promising molecules toward future preclinical and clinical steps.
Who could benefit from this research
Good fit: People living with HIV—especially those with protease inhibitor resistance or with HIV-related neurocognitive symptoms—are the likely future candidates for therapies developed from this research.
Not a fit: People without HIV or those stably suppressed on current first-line therapy may not see direct benefit from this early-stage drug development work.
Why it matters
Potential benefit: If successful, this work could produce HIV medicines that work against resistant virus strains, last longer between doses, and better protect the brain from HIV-related damage.
How similar studies have performed: Existing protease inhibitors have been effective in cART but resistance and toxicity remain, and while protease inhibitor development has a track record, nonpeptide designs with improved brain penetration are more experimental.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Ghosh, Arun K — Purdue University
- Study coordinator: Ghosh, Arun K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.