Noninvasive genetic testing for glioblastoma patients using ultrasound
Official title: Sonobiopsy for Noninvasive Genetic Evaluation of Glioblastoma Patients
Funded at Washington University · NIH-11000275 · Data updated 2026-11-12
This study is testing a new, non-invasive way to gather important genetic information from glioblastoma tumors using focused ultrasound, which could help doctors better diagnose and manage the condition, and it’s for patients who are dealing with glioblastoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $645,323 |
| NIH project number | 5R01CA276174-03 |
| Project ID | NIH-11000275 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are scheduled for surgery.
✕Less likely to help
Patients with other types of brain tumors or those who are not candidates for surgery may not benefit from this research.
What this research studies
This research investigates a new method called sonobiopsy, which uses focused ultrasound to collect genetic information from glioblastoma tumors without the need for invasive surgery. By analyzing blood samples from patients, the study aims to identify genetic markers that can help in diagnosing and managing glioblastoma more effectively. The research will involve a clinical trial where patients will be randomly assigned to receive either the sonobiopsy or a sham procedure to assess the safety and effectiveness of this technique. The ultimate goal is to improve the clinical management of glioblastoma patients by providing crucial genetic insights.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective ways to diagnose and monitor glioblastoma, potentially improving patient outcomes.
How similar studies have gone: Previous studies have shown promise with noninvasive biopsy techniques in other cancers, suggesting potential success for this novel approach in glioblastoma.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Leuthardt, Eric Claude — Washington University
- Study coordinator: Leuthardt, Eric Claude
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.