Noninvasive brain stimulation to reduce hyperexcitability in a Fragile X rat model

Who could benefit from this research

What this research studies

This project uses a rat model of Fragile X syndrome to test whether applying low-frequency repetitive transcranial magnetic stimulation to the prefrontal cortex can reduce brain hyperexcitability and alter gamma activity. The researchers will assess changes in anxiety, memory, and cognitive flexibility through three behavioral tasks, followed by brain recordings to measure multi-unit activity and local field potentials. After stimulation, the same tests will be repeated to see how results track with neural changes. The goal is to identify potential translational biomarkers that could guide future human studies and help people with Fragile X/ASD.

Why it matters

Where this research is happening

• Kansas State University
  Manhattan, United States Active

Researchers

• Principal investigator: Plakke Anderson, Bethany — Kansas State University
• Study coordinator: Plakke Anderson, Bethany

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.