Noninvasive brain modulation using sound and genetics
iSonogenetics for incisionless cell-type-specific neuromodulation of non-human primate brains
This study is exploring a new way to safely change brain activity using sound waves instead of surgery, which could help us better understand how the brain works and create more effective treatments for brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10655585 on NIH RePORTER |
What this research studies
This research aims to develop a new technique called incisionless sonogenetics (iSonogenetics) that allows for the targeted manipulation of brain activity without invasive procedures. By using focused ultrasound to deliver genetic material to specific neurons, the researchers hope to control brain circuits involved in cognitive behavior. This approach combines noninvasive delivery methods with genetic tools to enhance precision in treating brain disorders. The ultimate goal is to improve our understanding of brain function and develop targeted therapies for human brain disorders.
Who could benefit from this research
Good fit: Ideal candidates would be individuals with brain disorders who could benefit from targeted neuromodulation therapies.
Not a fit: Patients with conditions that do not involve specific neuronal circuit dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for various brain disorders.
How similar studies have performed: While the approach of using ultrasound for neuromodulation is being explored, this specific combination of techniques is novel and has not been extensively tested in humans.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Chen, Hong — Washington University
- Study coordinator: Chen, Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.