Non-surgical delivery of treatments to the retina using ultrasound
Acoustically targeted, high-resolution, site-specific, transretinal delivery of macromolecules
This study is exploring a new way to safely deliver treatments directly to the retina using focused ultrasound, which could help people with inherited retinal diseases without needing surgery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10706971 on NIH RePORTER |
What this research studies
This research focuses on developing a new method for delivering macromolecules and gene therapies directly to the retina without the need for surgery. By using focused ultrasound, the researchers aim to enhance the precision of treatment delivery, making it safer and more effective for patients with inherited retinal diseases. The approach involves injecting a microbubble contrast agent into a peripheral vein, which, when targeted by ultrasound, allows for the delivery of therapeutic agents to specific areas of the retina. This innovative technique could potentially overcome the challenges associated with current surgical methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with inherited retinal diseases who are at risk of vision loss or blindness.
Not a fit: Patients with retinal disorders that are not amenable to gene therapy or those who have already undergone surgical interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for patients suffering from retinal disorders, potentially restoring vision.
How similar studies have performed: Previous research has shown promise in using ultrasound for targeted drug delivery, indicating that this approach may be viable and effective.
Where this research is happening
Houston, United States
- Rice University — Houston, United States (Active)
Researchers
- Principal investigator: Szablowski, Jerzy Olgierd — Rice University
- Study coordinator: Szablowski, Jerzy Olgierd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.