Non-invasive urine tests for monitoring bladder cancer
Official title: Evaluation of Pre-Analytical Factors of Urine Samples for Urine Cancer Cell Cultures (UCCC) --A Non-Invasive Biomarker – in Monitoring Response and Recurrence of Bladder Cancer
Funded at Ohio State University · NIH-10922790 · Data updated 2026-11-12
This study is testing a new, easier way to check for bladder cancer using urine samples, which could help find out if the cancer comes back and how well treatments are working, making it more comfortable for patients than older methods.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 6, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $342,268 |
| NIH project number | 5U01CA278927-02 |
| Project ID | NIH-10922790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with bladder cancer who are undergoing treatment or monitoring for recurrence.
✕Less likely to help
Patients with other types of cancer or those who are not currently diagnosed with bladder cancer may not benefit from this research.
What this research studies
This research focuses on developing a new method to monitor bladder cancer using urine samples. By utilizing a technique called conditional reprogramming, researchers aim to create cancer cell cultures from urine, which can help detect cancer recurrence and predict responses to treatments. This approach is designed to be less invasive and more comfortable for patients compared to traditional methods like cystoscopy. The goal is to improve patient outcomes and reduce healthcare costs associated with bladder cancer monitoring.
Why it matters
Potential benefit: If successful, this research could provide a more accessible and cost-effective way for patients to monitor bladder cancer recurrence.
How similar studies have gone: Previous research has shown promise in using non-invasive biomarkers for cancer detection, suggesting that this approach could be effective.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Liu, Xuefeng — Ohio State University
- Study coordinator: Liu, Xuefeng
Related research
Other NIH-funded projects on the same topics.
-
Cruciferous vegetable program to lower bladder cancer recurrence
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-
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This project offers a urine test that looks for multiple cancer markers to help people treated for bladder cancer spot recurrence sooner.
-
Improving urine-based cancer cell cultures to monitor bladder cancer treatment and recurrence
This project tests whether collecting and handling urine the right way lets doctors grow bladder cancer cells from urine to help monitor treatment response and catch recurrence for people with bladder cancer.
-
Using cruciferous vegetables to help prevent bladder cancer from coming back
This study is looking at whether eating more cruciferous vegetables, like broccoli and kale, can help people with non-muscle invasive bladder cancer lower their chances of the cancer coming back or getting worse, and it’s designed for patients who want to try a natural way to support their health through diet.
-
A new urine test to detect bladder cancer recurrence
This study is testing a new, easy urine test called BCDx that uses advanced technology to check for signs of bladder cancer without needing any invasive procedures, making it a friendlier option for patients who need to monitor their condition.
-
Keloid recurrence study using multi-omics in diverse patients
A research effort will look at why keloids come back after surgery, especially in African American patients, using comprehensive molecular data from patient samples.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.