Non-invasive treatment for brain tumors using ultrasound and MRI guidance
Transcranial MRI- and Ultrasound- guided histotripsy (tcMR-USgHt) system
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11108633
This study is testing a new way to treat brain tumors using a special combination of MRI and ultrasound that aims to destroy tumors without surgery, making it safer and easier for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11108633 on ClinicalTrials.gov |
What this research studies
This research aims to develop a new system that combines transcranial magnetic resonance imaging (MRI) and ultrasound to treat brain tumors without the need for invasive surgery. By using focused ultrasound pulses, the system can create mechanical ablation in brain tissue, targeting tumors while minimizing damage to surrounding healthy tissue. The approach is designed to overcome the limitations of current treatments like surgery and radiation therapy, which can have significant side effects. Patients will be monitored closely to assess the effectiveness and safety of this innovative treatment method.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with primary brain tumors or brain metastases who are seeking alternative treatment options.
Not a fit: Patients with non-brain tumors or those who are not candidates for any form of tumor ablation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer, non-invasive treatment option for patients with brain tumors.
How similar studies have performed: Previous research has shown promising results with similar ultrasound-based ablation techniques, indicating potential for success in this novel application.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XU, ZHEN — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: XU, ZHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.