Non-invasive testing for glioma molecular markers using MRI and AI
Virtual Biopsy with Tissue-level Accuracy in Glioma
This study is working on a new, safer way to find important markers in brain tumors called gliomas using regular MRI scans and smart computer technology, so patients can avoid risky procedures like biopsies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11045035 on NIH RePORTER |
What this research studies
This research aims to develop a non-invasive method to determine critical molecular markers in gliomas, such as IDH, 1p/19q, and MGMT, using standard MRI images and advanced deep learning techniques. Currently, obtaining these markers requires invasive procedures like biopsies or surgeries, which carry risks and costs. By leveraging artificial intelligence, the project seeks to achieve tissue-level accuracy in identifying these markers, potentially transforming glioma management and improving patient outcomes. The research will validate its findings beyond initial studies to ensure reliability and effectiveness.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with gliomas who require molecular marker testing for treatment planning.
Not a fit: Patients with non-glioma brain tumors or those who have already undergone extensive treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the need for invasive procedures in glioma patients, leading to safer and quicker diagnoses.
How similar studies have performed: Preliminary studies have shown promising results with similar non-invasive approaches, achieving high accuracy rates, indicating potential for success in this research.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Maldjian, Joseph a — Ut Southwestern Medical Center
- Study coordinator: Maldjian, Joseph a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.