Non-invasive control of calcium signaling in brain cells
Genetically-Encoded, Non-Invasive and Wireless Modulation of Calcium Dynamics in Astrocytes With Spatiotemporal Precision and Depth
This study is exploring a new way to safely and easily influence brain cells called astrocytes, which help neurons communicate, to better understand how they work and possibly find new treatments for brain-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-11030840 on NIH RePORTER |
What this research studies
This research focuses on developing a novel technique to non-invasively and wirelessly modulate the activity of astrocytes, which are crucial brain cells involved in neuronal communication. By utilizing a method called FeRIC, the researchers aim to control calcium signaling in these cells with high precision, which could enhance our understanding of their role in brain function and behavior. The approach combines radiofrequency waves with genetically encoded actuators to manipulate astrocytic activity in real-time, potentially leading to new therapeutic strategies for neuropsychiatric and neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neuropsychiatric or neurodegenerative conditions that may be linked to astrocytic dysfunction.
Not a fit: Patients with conditions unrelated to astrocytic function or those who do not have neuropsychiatric or neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to dysfunctional astrocyte activity, such as neurodegenerative diseases.
How similar studies have performed: While the specific FeRIC technique is novel, previous research has shown promise in manipulating astrocytic function, indicating potential for success in this area.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Liu, Chunlei — University of California Berkeley
- Study coordinator: Liu, Chunlei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.