Non-invasive blood test for detecting gene mutations in lung cancer
Official title: Rapid, Multiplexed Biosensor for Non-Invasive Detection of Gene Mutations and Personalization of Therapy in Non-Small Cell Lung Cancer
Funded at Giner, INC. · NIH-10480889 · Data updated 2026-11-12
This study is working on a quick and easy blood test that can spot specific gene changes in non-small cell lung cancer, helping doctors tailor treatments for patients without needing a more invasive tissue biopsy.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Giner, INC. NIH-funded |
| Lab location | 1 site (Newton, United States) |
| Project start | September 17, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $997,685 |
| NIH project number | 5R44CA240021-03 |
| Project ID | NIH-10480889 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who may benefit from targeted therapies based on their genetic mutations.
✕Less likely to help
Patients with other types of lung cancer or those who do not have detectable gene mutations may not receive benefit from this research.
What this research studies
This research focuses on developing a rapid and sensitive biosensor that can detect gene mutations in non-small cell lung cancer (NSCLC) using a simple blood sample. By analyzing circulating tumor DNA (ctDNA), which is a specific cancer biomarker, the study aims to provide a non-invasive alternative to traditional tissue biopsies. The approach involves using an electrochemical detection method to identify single-base mutations in the EGFR gene, which are crucial for personalizing cancer therapy. The technology will be validated with patient plasma samples and integrated into a microfluidic device for efficient testing.
Why it matters
Potential benefit: If successful, this research could enable more personalized and effective treatment options for patients with non-small cell lung cancer.
How similar studies have gone: Previous research has shown promising results with similar non-invasive liquid biopsy approaches, indicating potential for success in this novel application.
Where this research is happening
-
Giner, INC.
Newton, United States Active
Researchers
- Principal investigator: Argun, Avni a — Giner, INC.
- Study coordinator: Argun, Avni a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.