Non-invasive blood test for detecting gene mutations in lung cancer
Rapid, Multiplexed Biosensor for Non-Invasive Detection of Gene Mutations and Personalization of Therapy in Non-Small Cell Lung Cancer
This study is working on a quick and easy blood test that can spot specific gene changes in non-small cell lung cancer, helping doctors tailor treatments for patients without needing a more invasive tissue biopsy.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Giner, INC. NIH-funded |
| Lab location | 1 site (Newton, United States) |
| Project ID | NIH-10480889 on NIH RePORTER |
What this research studies
This research focuses on developing a rapid and sensitive biosensor that can detect gene mutations in non-small cell lung cancer (NSCLC) using a simple blood sample. By analyzing circulating tumor DNA (ctDNA), which is a specific cancer biomarker, the study aims to provide a non-invasive alternative to traditional tissue biopsies. The approach involves using an electrochemical detection method to identify single-base mutations in the EGFR gene, which are crucial for personalizing cancer therapy. The technology will be validated with patient plasma samples and integrated into a microfluidic device for efficient testing.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who may benefit from targeted therapies based on their genetic mutations.
Not a fit: Patients with other types of lung cancer or those who do not have detectable gene mutations may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable more personalized and effective treatment options for patients with non-small cell lung cancer.
How similar studies have performed: Previous research has shown promising results with similar non-invasive liquid biopsy approaches, indicating potential for success in this novel application.
Where this research is happening
Newton, United States
- Giner, INC. — Newton, United States (Active)
Researchers
- Principal investigator: Argun, Avni a — Giner, INC.
- Study coordinator: Argun, Avni a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.