NoMore: a digitally controlled nicotine inhaler to help people quit smoking
Official title: Assessment of a Digitally Controlled Aerosolized Nicotine Replacement Therapy
Funded at Predictably Human, INC. · NIH-11334398 · Data updated 2026-11-12
A new prescription aerosol nicotine replacement device called NoMore aims to help people quit smoking by delivering nicotine in a controlled, digital way and tapering off over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Predictably Human, INC. NIH-funded |
| Lab location | 1 site (Darien, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,106,679 |
| NIH project number | 5R42DA060773-03 |
| Project ID | NIH-11334398 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who smoke and are seeking to quit, particularly those who have not achieved long-term abstinence with current therapies.
✕Less likely to help
People not seeking nicotine replacement or those who cannot use inhaled therapies may not benefit.
What this research studies
This project focuses on a digitally controlled nicotine aerosol that mimics smoking so people can switch away from cigarettes. It plans to support transition from smoking to NoMore, then gradually reduce nicotine to help overcome dependence. The researchers will compare NoMore to standard medications to see if it improves abstinence and reduces smoking more effectively. Early studies suggest NoMore may produce higher quit rates and greater reductions in smoking than existing treatments.
Why it matters
Potential benefit: If successful, NoMore could offer a more effective option for quitting smoking and reducing related health risks.
How similar studies have gone: Preliminary studies indicate higher abstinence and reduced smoking with a nicotine aerosol similar to NoMore compared to placebo.
Where this research is happening
-
Predictably Human, INC.
Darien, United States Active
Researchers
- Principal investigator: Davis, James M — Predictably Human, INC.
- Study coordinator: Davis, James M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.