NK cells and calming lung inflammation in infants with RSV
NK cell inflammation resolution circuits in pediatric RSV infection
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11241960
Looks at whether NK immune cells and natural 'pro-resolving' molecules help reduce dangerous lung inflammation in infants and young children with RSV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11241960 on ClinicalTrials.gov |
What this research studies
If my child is hospitalized with RSV, researchers will collect airway and blood samples to study immune cells called NK cells and natural pro-resolving fat molecules (SPMs). They'll compare these immune measurements between children who recover quickly and those with long-lasting, severe lung inflammation to see what is different. The team will combine tests on human samples with lab models to learn how impaired NK cell resolution may drive ongoing lung damage. The aim is to identify immune pathways that could become new treatments to prevent respiratory failure.
Who could benefit from this research
Good fit: Infants and young children diagnosed with RSV infection, especially those hospitalized for bronchiolitis or showing low oxygen levels, would be ideal candidates.
Not a fit: Healthy children, people without RSV, or those with unrelated lung conditions are unlikely to benefit directly from this project.
Why it matters
Potential benefit: Could point to new treatments that help NK cells or boost resolving molecules to shorten severe RSV inflammation and reduce respiratory failure in infants.
How similar studies have performed: Mouse studies from the team showed SPMs reduce RSV lung inflammation, but confirming this mechanism and benefit in human children remains new.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUVALL, MELODY G. — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: DUVALL, MELODY G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.