Nighttime blood pressure, sleep, and heart risk for people with HIV in Tanzania
HIV, Sleep, Nocturnal Non-dipping, and Cardiovascular Disease: a Tanzanian Cohort
This project checks whether people living with HIV in Tanzania have higher nighttime blood pressure and less nighttime blood-pressure dipping during sleep, and whether that links to early signs of heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11140485 on NIH RePORTER |
What this research studies
You would be part of a group of 500 people living with HIV on stable antiretroviral therapy and 500 HIV-negative adults followed in Tanzania. Each participant will wear a portable 24-hour ambulatory blood pressure cuff, have sleep and nerve-activity measurements, and get tests for early (preclinical) heart disease at repeated visits. The same measures are repeated over about 36 months to see how nighttime blood pressure patterns change over time and relate to early heart damage. The team will compare the two groups to find biological pathways that might become targets for future prevention or treatment.
Who could benefit from this research
Good fit: Adults aged 21 and older living with HIV on stable antiretroviral therapy in Tanzania, and comparable HIV-uninfected adults for comparison, are the ideal participants.
Not a fit: People under 21, those outside the Tanzanian recruitment area, or those unable or unwilling to wear a 24-hour monitor or attend follow-up visits may not directly benefit from participating.
Why it matters
Potential benefit: If successful, this work could reveal treatable blood-pressure or sleep-related causes of higher heart risk in people with HIV and guide better prevention strategies.
How similar studies have performed: Small cross-sectional studies have suggested non-dipping is more common in people with HIV, but long-term cohort data linking non-dipping to later heart disease are limited.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Peck, Robert N — Weill Medical Coll of Cornell Univ
- Study coordinator: Peck, Robert N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.