Next generation gene expression analysis
Funded at Merrimack College · NIH-11582555 · Data updated 2026-11-12
A study exploring how cells manage stressed proteins to understand diseases like neurodegeneration and cancer, using advanced gene expression techniques.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Merrimack College NIH-funded |
| Lab location | 1 site (North Andover, United States) |
| Project start | May 1, 2018 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $391,980 |
| NIH project number | 7R35GM127089-09 |
| Project ID | NIH-11582555 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable; this is a basic science project at a college research lab (no direct patient participation).
✕Less likely to help
No immediate benefit to patients since the work is preclinical/basic science.
What this research studies
This project looks at how cells cope with misfolded proteins in the ER and how the unfolded protein response affects gene expression, translation, and RNA/protein turnover. It uses time-series data and modeling to map the dynamic events during ER stress. The results could reveal new targets or timing strategies for therapies addressing diseases where protein misfolding plays a role.
Why it matters
Potential benefit: It could identify new biomarkers or therapeutic targets related to how cells respond to protein stress.
How similar studies have gone: Previous work showed that pulse-like mRNA changes occur during ER stress, supporting this approach with potential advances.
Where this research is happening
-
Merrimack College
North Andover, United States Active
Researchers
- Principal investigator: Vogel, Christine — Merrimack College
- Study coordinator: Vogel, Christine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.