New Ways to Use Epigenetic Therapies for Cancer
Official title: Epigenetic Therapies - New Approaches
Funded at Coriell Institute for Medical Research · NIH-11140513 · Data updated 2026-11-12
This project explores new ways to use epigenetic therapies to help patients with breast cancer and other cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coriell Institute for Medical Research NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project start | August 16, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $2,521,916 |
| NIH project number | 5P50CA254897-05 |
| Project ID | NIH-11140513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with breast cancer and other types of cancer who may benefit from or are resistant to current epigenetic therapies could be ideal candidates for future clinical applications of this research.
✕Less likely to help
Patients without cancer or those whose cancer does not involve the specific epigenetic changes targeted by these therapies may not directly benefit from this particular research.
What this research studies
Epigenetics involves changes in how our genes work, which can drive cancer growth and resistance to treatments. Researchers are looking for new ways to reprogram these gene changes to fight cancer more effectively. This work builds on existing epigenetic therapies that are already helping many cancer patients. The goal is to overcome current challenges, like finding better ways to predict who will respond and understanding why these therapies work differently in various cancer types.
Why it matters
Potential benefit: If successful, this work could lead to more effective epigenetic treatments for breast cancer and other cancers, potentially improving patient outcomes and overcoming resistance to current therapies.
How similar studies have gone: Epigenetic therapies have already led to four FDA-approved drugs that benefit tens of thousands of cancer patients annually, indicating a strong foundation of prior success in this field.
Where this research is happening
-
Coriell Institute for Medical Research
Camden, United States Active
Researchers
- Principal investigator: Issa, Jean-Pierre J. — Coriell Institute for Medical Research
- Study coordinator: Issa, Jean-Pierre J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.