New ways to use antibiotics to fight drug-resistant bacteria
Novel Strategies for Antibiotic Combinations to Combat Gram-negative Superbugs
This study is looking at how different antibiotics can be combined to better fight tough infections caused by superbugs that don't respond to regular treatments, helping patients get better and stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10733429 on NIH RePORTER |
What this research studies
This research focuses on developing effective antibiotic combinations to combat Gram-negative superbugs, particularly those resistant to current treatments. The team is investigating how different antibiotics can work together to enhance their effectiveness and prevent the bacteria from developing further resistance. By optimizing dosing strategies, the goal is to achieve better outcomes for patients suffering from infections caused by these dangerous bacteria. This research is crucial as it addresses a growing public health threat posed by antibiotic-resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by carbapenem-resistant Enterobacteriaceae or similar Gram-negative bacteria.
Not a fit: Patients with infections caused by bacteria that are not Gram-negative or those who do not respond to antibiotic treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with infections caused by drug-resistant bacteria.
How similar studies have performed: Other research has shown promise in using antibiotic combinations to combat resistant bacteria, indicating that this approach could be effective.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Tsuji, Brian — State University of New York at Buffalo
- Study coordinator: Tsuji, Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.