New ways to understand and treat fibrous dysplasia
Official title: Novel Strategies for Understanding and Treating Fibrous Dysplasia
Funded at University of California, San Francisco · NIH-11073066 · Data updated 2026-11-12
This study is looking at fibrous dysplasia, a bone condition, to find out how we can improve bone health and healing, which could help people with osteoporosis and fractures by testing new treatments using mice and human cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $648,327 |
| NIH project number | 5R01AR081336-03 |
| Project ID | NIH-11073066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with fibrous dysplasia or those with conditions related to abnormal bone formation.
✕Less likely to help
Patients with bone disorders unrelated to fibrous dysplasia may not benefit from this research.
What this research studies
This research focuses on fibrous dysplasia, a bone disorder caused by genetic mutations that affect bone formation. The team aims to uncover the biological signals that regulate bone health and repair, which could lead to better treatments for conditions like osteoporosis and fractures. By utilizing advanced techniques such as mouse models and human stem cells, the researchers will explore new compounds that can target specific pathways involved in bone formation. This innovative approach may provide insights into enhancing bone repair and developing effective therapies for patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for fibrous dysplasia and related bone disorders, enhancing patients' quality of life.
How similar studies have gone: Previous research has shown promise in targeting similar biological pathways for bone disorders, indicating potential for success in this novel approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Hsiao, Edward C — University of California, San Francisco
- Study coordinator: Hsiao, Edward C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.