New Ways to Treat Bone Fractures and Pain
Novel treatments of fracture repair and bone pain
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11132912
This project is looking for new ways to manage pain after bone fractures without slowing down healing, especially for older adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11132912 on ClinicalTrials.gov |
What this research studies
Chronic pain and disability are common after bone fractures, particularly in older individuals. Current pain relief options, like NSAIDs, can sometimes hinder bone healing, while opioids carry their own risks. This project explores the role of a natural substance called CGRP, found in nerves around bones, to see if it helps bones heal but also contributes to long-lasting pain. Researchers are using mouse models of bone fracture to understand how CGRP affects both the healing process and pain signals. The goal is to find new pain medications that support healing and prevent chronic pain.
Who could benefit from this research
Good fit: Patients who experience bone fractures, particularly older adults, and those who suffer from chronic pain after a fracture, could potentially benefit from future treatments developed from this research.
Not a fit: Patients without bone fractures or related pain conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new pain medications for bone fractures that promote healing and reduce the risk of chronic pain, offering safer alternatives to current treatments.
How similar studies have performed: This research explores a novel approach by investigating the dual role of CGRP in both bone healing and pain, which is a relatively untested strategy for developing new analgesics.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHITE, FLETCHER A — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: WHITE, FLETCHER A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.