New Ways to Target Kidney Cancer
Strategies to Disrupt Oncogenic Transcription in RCC Tumors
This research looks for new and better ways to treat kidney cancer by targeting specific pathways that help tumors grow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11112428 on NIH RePORTER |
What this research studies
We are exploring how certain proteins, called YAP/TAZ, act as master controllers for kidney cancer growth. Our team will test new medications designed to block these YAP/TAZ proteins in models derived from patient tumors. We will also use advanced techniques to understand how these new treatments change the cancer cells at a very detailed level. Ultimately, we aim to develop combination therapies that are more effective against kidney cancer.
Who could benefit from this research
Good fit: This foundational research focuses on understanding kidney cancer at a molecular level, and while it uses patient-derived models, it is not currently recruiting human participants.
Not a fit: Patients not diagnosed with renal cell carcinoma would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective treatment options for patients with advanced kidney cancer.
How similar studies have performed: Preliminary studies suggest that targeting YAP/TAZ is a promising approach, and this work aims to develop first-in-class inhibitors.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Yi, Chunling — Georgetown University
- Study coordinator: Yi, Chunling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.