New ways to stop aggressive breast cancer from growing and spreading
Inhibiting tumor growth and metastasis in highly aggressive breast cancers with centrosome amplification
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-11123328
This research looks for new ways to stop aggressive breast cancers, especially those with a specific cell problem called centrosome amplification, from growing and spreading.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11123328 on ClinicalTrials.gov |
What this research studies
We are exploring how to stop aggressive breast cancers, like triple-negative breast cancer, that have too many centrosomes in their cells. These extra centrosomes are linked to faster tumor growth and spread throughout the body. Our approach involves targeting a protein called TACC3, which we believe can disrupt how these cancer cells divide and move. By interfering with TACC3, we hope to make cancer cells unable to divide properly, leading to their death, and also prevent them from migrating to other parts of the body.
Who could benefit from this research
Good fit: This research is focused on understanding and potentially treating patients with highly aggressive breast cancers, particularly those with centrosome amplification and p53 mutations, such as triple-negative breast cancer.
Not a fit: Patients with breast cancers that do not exhibit centrosome amplification or p53 mutations may not directly benefit from this specific research approach.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that specifically target aggressive breast cancers and prevent them from spreading, ultimately improving patient outcomes.
How similar studies have performed: While the role of centrosome amplification in cancer progression is recognized, this specific strategy of targeting TACC3 to induce multipolar mitosis and block metastasis in this context is a novel approach.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAHIN, OZGUR — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: SAHIN, OZGUR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.