New ways to measure how typhoid vaccines work in communities
Official title: Novel tools for measuring typhoid vaccine impact
Funded at Stanford University · NIH-11540719 · Data updated 2026-11-12
Researchers are testing simple, low-cost methods to measure how well typhoid vaccines reduce illness in communities where the disease is common.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $97,114 |
| NIH project number | 3R01AI181283-03S1 |
| Project ID | NIH-11540719 on NIH RePORTER |
Who could benefit from this research
✓Could help
Communities and individuals in typhoid-endemic regions participating in the related vaccine trial or living in similar settings may benefit from improved disease surveillance.
✕Less likely to help
People in settings without typhoid risk or without access to the trial sites may not directly benefit.
What this research studies
This project will use data from a large vaccine trial in Vellore, India to test three new tools for tracking typhoid burden: blood-based serology, wastewater phage detection, and genetic tracking of transmission. The team will compare these methods against standard clinical surveillance to see which provide reliable, scalable signals of population protection. The work is designed to happen alongside intensive clinical monitoring to ensure accuracy and relevance to real-world settings. If successful, these tools could make typhoid surveillance cheaper and more widespread in resource-limited areas.
Why it matters
Potential benefit: If these methods work, public health programs could monitor typhoid risk more efficiently and protect more people with timely interventions.
How similar studies have gone: Previous studies have shown promise for serology and wastewater signals, but this project tests multiple approaches together in a real-world trial.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Andrews, Jason Randolph — Stanford University
- Study coordinator: Andrews, Jason Randolph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.