New ways to find many cancer proteins
Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries
This project aims to create new, easy-to-use tools to find many different proteins in cancer cells, helping scientists better understand the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11138442 on NIH RePORTER |
What this research studies
Currently, finding many proteins in cancer cells is often slow and expensive because it relies on older methods. This project plans to develop a new strategy using tiny, engineered antibodies called nanobodies that can quickly identify hundreds to thousands of human proteins at once. These nanobodies will have special "barcodes" that make them easy to detect, allowing researchers to create large collections of these tools. This will make it much simpler and more affordable for cancer researchers to study proteins in detail.
Who could benefit from this research
Good fit: This project is focused on developing research tools, so it does not directly involve patients, but its future applications will benefit those with cancer.
Not a fit: Patients not affected by cancer or those not involved in future research utilizing these specific protein detection tools may not directly benefit from this foundational work.
Why it matters
Potential benefit: If successful, this work could lead to faster and more affordable ways for scientists to study cancer, potentially speeding up the discovery of new diagnostic tests and treatments.
How similar studies have performed: This project proposes a novel strategy and builds on recently developed cell-free platforms, suggesting it is a new and untested approach.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Hacohen, Nir — Broad Institute, INC.
- Study coordinator: Hacohen, Nir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.